The Impact of Statin Use and Breast Cancer Recurrence - A Retrospective Study in Singapore.

ABSTRACT:

Introduction

Statins, HMG-CoA reductase inhibitors, are commonly used cholesterol-lowering medications which are also increasingly recognized to have anti-cancer properties for various cancers, including breast cancer. Most clinical evidence supports a protective effect of statin on reducing breast cancer recurrence, particularly in hormone-receptor positive breast cancers.This study seeks to study the impact of statin use on breast cancer recurrence in an Asian population.

Methods

This is a retrospective study of patients diagnosed with breast cancer at the National Cancer Centre and Singapore General Hospital from 2005-2015. Statin use was defined as use after surgery. Associations between statin use, breast cancer recurrence and overall survival were estimated using Cox p

SUBMITTER: Sim Y 

PROVIDER: S-EPMC9008885 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature