The dynamic alteration of transcriptional regulation by crucial TFs during tumorigenesis of gastric cancer.

ABSTRACT:

Background

The mechanisms of Gastric cancer (GC) initiation and progression are complicated, at least partly owing to the dynamic changes of gene regulation during carcinogenesis. Thus, investigations on the changes in regulatory networks can improve the understanding of cancer development and provide novel insights into the molecular mechanisms of cancer.

Methods

Differential co-expression analysis (DCEA), differential gene regulation network (GRN) modeling and differential regulation analysis (DRA) were integrated to detect differential transcriptional regulation events between gastric normal mucosa and cancer samples based on GSE54129 dataset. Cytological experiments and IHC staining assays were used to validate the dynamic changes of CREB1 regulated targets in different

SUBMITTER: Yu B 

PROVIDER: S-EPMC9008954 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature