Pyruvate kinase, a metabolic sensor powering glycolysis, drives the metabolic control of DNA replication.

ABSTRACT:

Background

In all living organisms, DNA replication is exquisitely regulated in a wide range of growth conditions to achieve timely and accurate genome duplication prior to cell division. Failures in this regulation cause DNA damage with potentially disastrous consequences for cell viability and human health, including cancer. To cope with these threats, cells tightly control replication initiation using well-known mechanisms. They also couple DNA synthesis to nutrient richness and growth rate through a poorly understood process thought to involve central carbon metabolism. One such process may involve the cross-species conserved pyruvate kinase (PykA) which catalyzes the last reaction of glycolysis. Here we have investigated the role of PykA in regulating DNA replication in the mo

SUBMITTER: Horemans S 

PROVIDER: S-EPMC9009071 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature