Therapeutic Alliance and Rapport Modulate Responses to Psilocybin Assisted Therapy for Depression.

ABSTRACT: Background: Across psychotherapeutic frameworks, the strength of the therapeutic alliance has been found to correlate with treatment outcomes; however, its role has never been formally assessed in a trial of psychedelic-assisted therapy. We aimed to investigate the relationships between therapeutic alliance and rapport, the quality of the acute psychedelic experience and treatment outcomes. Methods: This 2-arm double-blind randomized controlled trial compared escitalopram with psychedelic-assisted therapy for moderate-severe depressive disorder (N = 59). This analysis focused on the psilocybin condition (n = 30), who received two oral doses of 25 mg psilocybin, 3-weeks apart, with psychological preparation, in-session support, and integration therapy. A new psyc

SUBMITTER: Murphy R 

PROVIDER: S-EPMC9009076 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature