Biological mechanisms of aging predict age-related disease co-occurrence in patients.

ABSTRACT: Genetic, environmental, and pharmacological interventions into the aging process can confer resistance to multiple age-related diseases in laboratory animals, including rhesus monkeys. These findings imply that individual mechanisms of aging might contribute to the co-occurrence of age-related diseases in humans and could be targeted to prevent these conditions simultaneously. To address this question, we text mined 917,645 literature abstracts followed by manual curation and found strong, non-random associations between age-related diseases and aging mechanisms in humans, confirmed by gene set enrichment analysis of GWAS data. Integration of these associations with clinical data from 3.01 million patients showed that age-related diseases associated with each of five aging mechanisms were

SUBMITTER: Fraser HC 

PROVIDER: S-EPMC9009120 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature