The Calcified Vasculature in Chronic Kidney Disease Secretes Factors that Inhibit Bone Mineralization.

ABSTRACT: Vascular calcification and bone disorder progress simultaneously in chronic kidney disease (CKD). Still, how the complex pathological mechanisms are linked is only sparsely understood. Up to now, the focus has been on the disturbed bone metabolism in developing vascular calcification. However, our group has recently demonstrated that vascular calcification has negative effects on bone formation and mineralization as shown in the bone of normal recipient rats transplanted with the calcified aorta from CKD rats. In the present in vitro study, the hypothesis of a direct crosstalk between the vasculature and bone was examined. Calcified aortas from 5/6 nephrectomized rats and normal aortas from control rats were excised and incubated ex vivo. The calcified aorta secreted large amounts of scler

SUBMITTER: Mace ML 

PROVIDER: S-EPMC9009125 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature