Ontology highlight
ABSTRACT:
SUBMITTER: Watanabe H
PROVIDER: S-EPMC9009129 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Watanabe Hisato H Okada Hiroyuki H Hirose Jun J Omata Yasunori Y Matsumoto Takumi T Matsumoto Morio M Nakamura Masaya M Saito Taku T Miyamoto Takeshi T Tanaka Sakae S
JBMR plus 20220214 4
We investigated the role of hematopoietically expressed homeobox protein (Hhex) in osteoclast development. Trimethylation of lysine 27 of histone H3 at the <i>cis</i>-regulatory element of <i>Hhex</i> was maintained and that of lysine 4 was reduced during receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclastogenesis, which was associated with a reduction of <i>Hhex</i> expression. Overexpression of <i>Hhex</i> in bone marrow-derived macrophages inhibited, whereas <i>Hhex</i> ...[more]