Arterial Stiffness and Long-Term Risk of Health Outcomes: The Framingham Heart Study.

ABSTRACT:

Background

Arterial stiffness increases with age and is associated with an increased risk of adverse outcomes on short-term follow-up (typically <10 years). Data regarding associations of arterial stiffness with health outcomes on longer-term follow-up are lacking.

Methods

We evaluated 7283 Framingham Study participants (mean age 50 years, 53% women) who underwent assessment of carotid-femoral pulse wave velocity (a marker of arterial stiffness) via applanation tonometry at one or more routine examinations. We used time-dependent Cox proportional hazards regression models to relate carotid-femoral pulse wave velocity to the incidence of health outcomes (updating carotid-femoral pulse wave velocity and all covariates at serial examinations).

Results

On long-term follow

SUBMITTER: Vasan RS 

PROVIDER: S-EPMC9009137 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature