Defective Mitochondrial Dynamics Underlie Manganese-Induced Neurotoxicity.

ABSTRACT: Perturbations in mitochondrial dynamics have been observed in most neurodegenerative diseases. Here, we focus on manganese (Mn)-induced Parkinsonism-like neurodegeneration, a disorder associated with the preferential of Mn in the basal ganglia where the mitochondria are considered an early target. Despite the extensive characterization of the clinical presentation of manganism, the mechanism by which Mn mediated mitochondrial toxicity is unclear. In this study we hypothesized whether Mn exposure alters mitochondrial activity, including axonal transport of mitochondria and mitochondrial dynamics, morphology, and network. Using primary neuron cultures exposed to 100 μM Mn (which is considered the threshold of Mn toxicity in vitro) and intraperitoneal injections of MnCl₂ (25mg/kg)

SUBMITTER: Morcillo P 

PROVIDER: S-EPMC9009155 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature