Visceral sensitivity modulation by faecal microbiota transplantation: the active role of gut bacteria in pain persistence.

ABSTRACT:

Abstract

Recent findings linked gastrointestinal disorders characterized by abdominal pain to gut microbiota composition. The present work aimed to evaluate the power of gut microbiota as a visceral pain modulator and, consequently, the relevance of its manipulation as a therapeutic option in reversing postinflammatory visceral pain persistence. Colitis was induced in mice by intrarectally injecting 2,4-dinitrobenzenesulfonic acid (DNBS). The effect of faecal microbiota transplantation from viscerally hypersensitive DNBS-treated and naive donors was evaluated in control rats after an antibiotic-mediated microbiota depletion. Faecal microbiota transplantation from DNBS donors induced a long-lasting visceral hypersensitivity in control rats. Pain threshold trend correlated with major

SUBMITTER: Lucarini E 

PROVIDER: S-EPMC9009324 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature