A model of multiple tumor marker for lymph node metastasis assessment in colorectal cancer: a retrospective study.

ABSTRACT:

Background

Assessment of colorectal cancer (CRC) lymph node metastasis (LNM) is critical to the decision of surgery, prognosis, and therapy strategy. In this study, we aimed to develop and validate a multiple tumor marker nomogram for predicting LNM in CRC patients.

Methods

A total of 674 patients who met the inclusion criteria were collected and randomly divided into primary cohort and internal test cohort at a ratio of 7:3. An external test cohort enrolled 178 CRC patients from the West China Hospital. Clinicopathologic variables were obtained from electronic medical records. The least absolute shrinkage and selection operator (LASSO) and interquartile range analysis were carried out for variable dimensionality reduction and feature selection. Multivariate logistic regress

SUBMITTER: Fu J 

PROVIDER: S-EPMC9009328 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature