Determinants of B-Cell Compartment Hyperactivation in European Adolescents Living With Perinatally Acquired HIV-1 After Over 10 Years of Suppressive Therapy.

ABSTRACT:

Background

Despite a successful antiretroviral therapy (ART), adolescents living with perinatally acquired HIV (PHIV) experience signs of B-cell hyperactivation with expansion of 'namely' atypical B-cell phenotypes, including double negative (CD27-IgD-) and termed age associated (ABCs) B-cells (T-bet+CD11c+), which may result in reduced cell functionality, including loss of vaccine-induced immunological memory and higher risk of developing B-cells associated tumors. In this context, perinatally HIV infected children (PHIV) deserve particular attention, given their life-long exposure to chronic immune activation.

Methods

We studied 40 PHIV who started treatment by the 2^nd year of life and maintained virological suppression for 13.5 years, with 5/40 patients experie

SUBMITTER: Ruggiero A 

PROVIDER: S-EPMC9009387 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature