The Role of Inorganics in Preeclampsia Assessed by Multiscale Multimodal Characterization of Placentae.

ABSTRACT: Preeclampsia is one of the most dangerous diseases in pregnancy. Because of the hypertensive nature of preeclampsia, placental calcifications are believed to be a predictor for its occurrence, analogous to their role in cardiovascular diseases. However, the prevalence and the relevance of calcifications for the clinical outcome with respect to preeclampsia remains controversial. In addition, the role of other inorganic components present in the placental tissue in the development of preeclampsia has rarely been investigated. In this work, we therefore characterized inorganic constituents in placental tissue in groups of both normotensive and preeclamptic patients (N = 20 each) using a multi-scale and multi-modal approach. Examinations included elemental analysis (metallomics), sonog

SUBMITTER: Rduch T 

PROVIDER: S-EPMC9009444 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature