Plasmalogens Regulate Retinal Connexin 43 Expression and Muller Glial Cells Gap Junction Intercellular Communication and Migration.

ABSTRACT: Plasmalogens are a specific glycerophospholipid subtype characterized by a vinyl-ether bound at their sn-1 moiety. Their biosynthesis is initiated in the peroxisome by dihydroxyacetone phosphate-acyltransferase (DHAPAT), which is encoded by the DAPAT gene. Previous studies have shown that plasmalogen-deficient mice exhibit major physiological dysfunctions including several eye defects, among which abnormal vascular development of the retina and a reactive activation of macroglial Müller cells. Interestingly, plasmalogen deficiency in mice is also associated with a reduced expression of brain connexin 43 (Cx43). Cx43 is the main connexin subtype of retinal glial cells and is involved in several cellular mechanisms such as calcium-based gap junction intercellular communication

SUBMITTER: Karadayi R 

PROVIDER: S-EPMC9009447 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature