Ontology highlight
ABSTRACT:
SUBMITTER: Carraro G
PROVIDER: S-EPMC9009537 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Carraro Gianni G Langerman Justin J Sabri Shan S Lorenzana Zareeb Z Purkayastha Arunima A Zhang Guangzhu G Konda Bindu B Aros Cody J CJ Calvert Ben A BA Szymaniak Aleks A Wilson Emily E Mulligan Michael M Bhatt Priyanka P Lu Junjie J Vijayaraj Preethi P Yao Changfu C Shia David W DW Lund Andrew J AJ Israely Edo E Rickabaugh Tammy M TM Ernst Jason J Mense Martin M Randell Scott H SH Vladar Eszter K EK Ryan Amy L AL Plath Kathrin K Mahoney John E JE Stripp Barry R BR Gomperts Brigitte N BN
Nature medicine 20210506 5
Cystic fibrosis (CF) is a lethal autosomal recessive disorder that afflicts more than 70,000 people. People with CF experience multi-organ dysfunction resulting from aberrant electrolyte transport across polarized epithelia due to mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CF-related lung disease is by far the most important determinant of morbidity and mortality. Here we report results from a multi-institute consortium in which single-cell transcriptomics ...[more]