The nuclear lamina binds the EBV genome during latency and regulates viral gene expression.

ABSTRACT: The Epstein Barr virus (EBV) infects almost 95% of the population worldwide. While typically asymptomatic, EBV latent infection is associated with several malignancies of epithelial and lymphoid origin in immunocompromised individuals. In latently infected cells, the EBV genome persists as a chromatinized episome that expresses a limited set of viral genes in different patterns, referred to as latency types, which coincide with varying stages of infection and various malignancies. We have previously demonstrated that latency types correlate with differences in the composition and structure of the EBV episome. Several cellular factors, including the nuclear lamina, regulate chromatin composition and architecture. While the interaction of the viral genome with the nuclear lamina has been stu

SUBMITTER: Caruso LB 

PROVIDER: S-EPMC9009669 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature