Association between serum β2-microglobulin and mortality in Japanese peritoneal dialysis patients: A cohort study.

ABSTRACT:

Background

Higher serum β2-microglobulin (B2M) concentrations are associated with higher mortality in the general population, non-dialyzed chronic kidney disease patients and patients receiving hemodialysis (HD). However, this relationship among patients on peritoneal dialysis (PD) has not been validated.

Methods

We collected baseline data for 3,011 prevalent PD patients from a nationwide dialysis registry in Japan at the end of 2010. Clinical outcomes for 9 years were then evaluated using the registry at the end of 2011 to 2019. All-cause and cardiovascular (CV) mortality was assessed using Cox regression analysis and competing-risks regression analysis, respectively. We used multiple imputation to deal with missing covariate data.

Results

During a median follow-up o

SUBMITTER: Maruyama Y 

PROVIDER: S-EPMC9009671 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature