Candidate genetic variants and antidepressant-related fall risk in middle-aged and older adults.

ABSTRACT:

Background

Antidepressant use has been associated with increased fall risk. Antidepressant-related adverse drug reactions (e.g. orthostatic hypotension) depend partly on genetic variation. We hypothesized that candidate genetic polymorphisms are associated with fall risk in older antidepressant users.

Methods

The association between antidepressant use and falls was cross-sectionally investigated in a cohort of Dutch older adults by logistic regression analyses. In case of significant interaction product term of antidepressant use and candidate polymorphism, the association between the variant genotype and fall risk was assessed within antidepressant users and the association between antidepressant use and fall risk was investigated stratified per genotype. Secondly, a look-u

SUBMITTER: Pronk AC 

PROVIDER: S-EPMC9009709 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature