Inter-paralog amino acid inversion events in large phylogenies of duplicated proteins.

ABSTRACT: Connecting protein sequence to function is becoming increasingly relevant since high-throughput sequencing studies accumulate large amounts of genomic data. In order to go beyond the existing database annotation, it is fundamental to understand the mechanisms underlying functional inheritance and divergence. If the homology relationship between proteins is known, can we determine whether the function diverged? In this work, we analyze different possibilities of protein sequence evolution after gene duplication and identify "inter-paralog inversions", i.e., sites where the relationship between the ancestry and the functional signal is decoupled. The amino acids in these sites are masked from being recognized by other prediction tools. Still, they play a role in functional divergence and cou

SUBMITTER: Pascarelli S 

PROVIDER: S-EPMC9009777 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature