Evaluation of the Use of Cancer Registry Data for Comparative Effectiveness Research.

ABSTRACT:

Importance

Researchers often analyze cancer registry data to assess for differences in survival among cancer treatments. However, the retrospective, nonrandomized design of these analyses raises questions about study validity.

Objective

To examine the extent to which comparative effectiveness analyses using observational cancer registry data produce results concordant with those of randomized clinical trials.

Design, setting, and participants

In this comparative effectiveness study, a total of 141 randomized clinical trials referenced in the National Comprehensive Cancer Network Clinical Practice Guidelines for 8 common solid tumor types were identified. Data on participants within the National Cancer Database (NCDB) diagnosed between 2004 and 2014, matching the eligi

SUBMITTER: Kumar A 

PROVIDER: S-EPMC9009816 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature