Transcriptome-wide association studies: a view from Mendelian randomization.

ABSTRACT:

Background

Genome-wide association studies (GWASs) have identified thousands of genetic variants that are associated with many complex traits. However, their biological mechanisms remain largely unknown. Transcriptome-wide association studies (TWAS) have been recently proposed as an invaluable tool for investigating the potential gene regulatory mechanisms underlying variant-trait associations. Specifically, TWAS integrate GWAS with expression mapping studies based on a common set of variants and aim to identify genes whose GReX is associated with the phenotype. Various methods have been developed for performing TWAS and/or similar integrative analysis. Each such method has a different modeling assumption and many were initially developed to answer different biological questions. C

SUBMITTER: Zhu H 

PROVIDER: S-EPMC9009829 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature