Therapeutic Targets for Heart Failure Identified Using Proteomics and Mendelian Randomization.

ABSTRACT:

Background

Heart failure (HF) is a highly prevalent disorder for which disease mechanisms are incompletely understood. The discovery of disease-associated proteins with causal genetic evidence provides an opportunity to identify new therapeutic targets.

Methods

We investigated the observational and causal associations of 90 cardiovascular proteins, which were measured using affinity-based proteomic assays. First, we estimated the associations of 90 cardiovascular proteins with incident heart failure by means of a fixed-effect meta-analysis of 4 population-based studies, composed of a total of 3019 participants with 732 HF events. The causal effects of HF-associated proteins were then investigated by Mendelian randomization, using cis-protein quantitative loci genetic

SUBMITTER: Henry A 

PROVIDER: S-EPMC9010023 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature