Leveraging large observational studies to discover genetic determinants of drug concentrations: A proof-of-concept study.

ABSTRACT: Large, observational genetic studies are commonly used to identify genetic factors associated with diseases and disease-related traits. Such cohorts have not been commonly used to identify genetic predictors of drug dosing or concentrations, perhaps because of the heterogeneity in drug dosing and formulation, and the random timing of blood sampling. We hypothesized that large sample sizes relative to traditional pharmacokinetic studies would compensate for this variability and enable the identification of pharmacogenetic predictors of drug concentrations. We performed a cross-sectional, proof-of-concept association study to replicate the well-established association between metoprolol concentrations and CYP2D6 genotype-inferred metabolizer phenotypes in participants from the Montreal Heart

SUBMITTER: Meloche M 

PROVIDER: S-EPMC9010273 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature