Nano gold-doped molecularly imprinted electrochemical sensor for rapid and ultrasensitive cortisol detection.

ABSTRACT: Rapid and sensitive detection of steroid hormone cortisol can benefit the diagnosis of diseases related to adrenal gland disorders and chronic stress. We report a molecularly imprinted polymer (MIP)-based electrochemical sensor that utilized nano gold-doped poly o-phenylenediamine (poly-o-PD) film to selectively determine trace level cortisol with enhanced sensitivity. The sensor detected cortisol levels by measuring the current change of the redox-active probes in response to the binding of target cortisol to the imprinted sites in the polymer. The gold-doped MIP (Au@MIP) sensor was prepared using a facile one-step in situ gold reduction and electropolymerization method to distribute high-density gold nanoparticles in the vicinity of the binding cavities. The in situ gold reduction promot

SUBMITTER: Yeasmin S 

PROVIDER: S-EPMC9010368 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature