Applying Mendelian randomization to appraise causality in relationships between nutrition and cancer.

ABSTRACT: Dietary factors are assumed to play an important role in cancer risk, apparent in consensus recommendations for cancer prevention that promote nutritional changes. However, the evidence in this field has been generated predominantly through observational studies, which may result in biased effect estimates because of confounding, exposure misclassification, and reverse causality. With major geographical differences and rapid changes in cancer incidence over time, it is crucial to establish which of the observational associations reflect causality and to identify novel risk factors as these may be modified to prevent the onset of cancer and reduce its progression. Mendelian randomization (MR) uses the special properties of germline genetic variation to strengthen causal inference regarding

SUBMITTER: Wade KH 

PROVIDER: S-EPMC9010389 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature