Inactivation of various variant types of SARS-CoV-2 by indoor-light-sensitive TiO₂-based photocatalyst.

ABSTRACT: Photocatalysts are promising materials for solid-state antiviral coatings to protect against the spread of pandemic coronavirus disease (COVID-19). This paper reports that copper oxide nanoclusters grafted with titanium dioxide (Cu_xO/TiO₂) inactivated the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, including its Delta variant, even under dark condition, and further inactivated it under illumination with a white fluorescent bulb. To investigate its inactivation mechanism, the denaturation of spike proteins of SARS-CoV-2 was examined by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and enzyme-linked immunosorbent assay (ELISA). In addition to spike proteins, fragmentation of ribonucleic acids in SARS-CoV-2 was investigated

SUBMITTER: Nakano R 

PROVIDER: S-EPMC9010443 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature