Evidence for widespread alterations in cortical microstructure after 32 h of sleep deprivation.

ABSTRACT: Cortical microstructure is influenced by circadian rhythm and sleep deprivation, yet the precise underpinnings of these effects remain unclear. The ratio between T₁-weighted and T₂-weighted magnetic resonance images (T₁w/T₂w ratio) has been linked to myelin levels and dendrite density and may offer novel insight into the intracortical microstructure of the sleep deprived brain. Here, we examined intracortical T₁w/T₂w ratio in 41 healthy young adults (26 women) before and after 32 h of either sleep deprivation (n = 18) or a normal sleep-wake cycle (n = 23). Linear models revealed significant group differences in T₁w/T₂w ratio change after 32 h in four clusters, including bilateral effects in the insular,

SUBMITTER: Voldsbekk I 

PROVIDER: S-EPMC9010475 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature