Correlation Among Body Composition Parameters and Long-Term Outcomes in Crohn's Disease After Anti-TNF Therapy.

ABSTRACT:

Background

The impact of the body composition on the pathophysiology and clinical course of Crohn's disease (CD) has not been fully elucidated.

Aims

To reveal the correlations among body composition and long-term outcomes in CD after anti-TNF therapy.

Methods

Ninety-one patients who received anti-TNF therapy as their first biologic treatment were enrolled. The skeletal muscle index (SMI), visceral and subcutaneous fat area (VFA, SFA), and the ratio of the VFA to SFA (mesenteric fat index; MFI) at the 3^rd lumbar level were measured using computed tomography (CT) imaging before the induction. The correlation among the body composition and outcomes were retrospectively analyzed.

Results

The 5-year cumulative secondary failure- and resection-free

SUBMITTER: Ando K 

PROVIDER: S-EPMC9010511 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature