Subunits of C1Q Are Associated With the Progression of Intermittent Claudication to Chronic Limb-Threatening Ischemia.

ABSTRACT:

Background

The pathophysiological mechanisms of intermittent claudication (IC) progression to chronic limb-threatening ischemia (CLTI) are still vague and which of patients with IC will become CLTI are unknown. This study aimed to investigate the key molecules and pathways mediating IC progression to CLTI by a quantitative bioinformatic analysis of a public RNA-sequencing database of patients with peripheral artery disease (PAD) to screen biomarkers discriminating IC and CLTI.

Methods

The GSE120642 dataset was downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) between IC and CLTI tissues were analyzed using the "edgeR" packages of R. The Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes enrichment analyses were perfo

SUBMITTER: Yao Z 

PROVIDER: S-EPMC9010542 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature