MiR-144-3p Is a Biomarker Related to Severe Corticosteroid-Dependent Asthma.

ABSTRACT: MicroRNAs are non-coding molecules that act both as regulators of the epigenetic landscape and as biomarkers for diseases, including asthma. In the era of personalized medicine, there is a need for novel disease-associated biomarkers that can help in classifying diseases into phenotypes for treatment selection. Currently, severe eosinophilic asthma is one of the most widely studied phenotypes in clinical practice, as many patients require higher and higher doses of corticosteroids, which in some cases fail to achieve the desired outcome. Such patients may only benefit from alternative drugs such as biologics, for which novel biomarkers are necessary. The objective of the study was to study the expression of miR-144-3p in order to discover its possible use as a diagnostic biomarker for seve

SUBMITTER: Rodrigo-Munoz JM 

PROVIDER: S-EPMC9010740 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature