The Role of Copy Number Variants in Gene Co-Expression Patterns for Luminal B Breast Tumors.

ABSTRACT: Gene co-expression networks have become a usual approach to integrate the vast amounts of information coming from gene expression studies in cancer cohorts. The reprogramming of the gene regulatory control and the molecular pathways depending on such control are central to the characterization of the disease, aiming to unveil the consequences for cancer prognosis and therapeutics. There is, however, a multitude of factors which have been associated with anomalous control of gene expression in cancer. In the particular case of co-expression patterns, we have previously documented a phenomenon of loss of long distance co-expression in several cancer types, including breast cancer. Of the many potential factors that may contribute to this phenomenology, copy number variants (CNVs) have been o

SUBMITTER: Hernandez-Gomez C 

PROVIDER: S-EPMC9010943 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature