[SARS-CoV-2 with transcription regulatory sequence motif mutation poses a greater threat].

ABSTRACT:

Objective

To analyze the mutations in transcription regulatory sequences (TRSs) of coronaviruss (CoV) to provide the basis for exploring the patterns of SARS-CoV-2 transmission and outbreak.

Methods

A combined evolutionary and molecular functional analysis of all sets of publicly available genomic data of viruses was performed.

Results

A leader transcription regulatory sequence (TRS-L) usually comprises the first 60-70 nts of the 5' UTR in a CoV genome, and the body transcription regulatory sequences (TRS-Bs) are located immediately upstream of the genes other than ORF1a and 1b. In each CoV genome, the TRS-L and TRS-Bs share a specific consensus sequence, namely the TRS motif. Any changes of nucleotide residues in the TRS motifs are defined as TRS motif mutations. Mut

SUBMITTER: Bei J 

PROVIDER: S-EPMC9010979 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature