Frequency of CXCR3⁺ CD8⁺ T-Lymphocyte Subsets in Peripheral Blood Is Associated With the Risk of Paradoxical Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Development in Advanced HIV Disease.

ABSTRACT:

Background

Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is a clinical aggravation of TB symptoms observed among a fraction of HIV coinfected patients shortly after the start of antiretroviral therapy (ART). Of note, TB-IRIS is characterized by exacerbated inflammation and tissue damage that occurs in response to the elevated production of CD4⁺ T cell-derived IFN-γ. Nevertheless, the possible participation of CD8⁺ T cells in TB-IRIS development remains unclear.

Methods

We performed a comprehensive assessment of the composition of CD8⁺ T cell memory subsets and their association with circulating inflammation-related molecules in TB-HIV coinfected patients initiating ART.

Results

We found that TB-IRIS indi

SUBMITTER: Tiburcio R 

PROVIDER: S-EPMC9011055 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature