Safety of High-Dose Vitamin D Supplementation Among Children Aged 0 to 6 Years: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Several health benefits of vitamin D have been suggested; however, the safety of high-dose supplementation in early childhood is not well described.

Objective

To systematically assess the risk of adverse events after high-dose supplementation with vitamin D reported in published randomized clinical trials.

Data sources

PubMed and ClinicalTrials.gov were searched through August 24, 2021.

Study selection

Randomized clinical trials of high-dose vitamin D supplementation in children aged 0 to 6 years, defined as greater than 1000 IU/d for infants (aged 0-1 year) and greater than 2000 IU/d for children aged 1 to 6 years.

Data extraction and synthesis

Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting

SUBMITTER: Brustad N 

PROVIDER: S-EPMC9011124 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature