B3GNT3 as a prognostic biomarker and correlation with immune cell infiltration in lung adenocarcinoma.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) is the most common malignant cancer in humans and because of low long-term survival rates, exploration of the molecular mechanisms underlying its progression, as well as novel prognostic predictors, is urgently needed. B3GNT3, a type II transmembrane protein located in the Golgi apparatus, is essential for forming extended core 1 oligosaccharides and is reportedly involved in malignant transformation.

Methods

The Cancer Genome Atlas (TCGA) and GSE68465 were used to analyze the expression of B3GNT3 in LUAD and normal tissues and overall survival. Real time quantitative polymerase chain reaction (qPCR) and western blot were conducted to measure the mRNA and protein levels of B3GNT3, respectively. Functional enrichment of differentially exp

SUBMITTER: Wu Y 

PROVIDER: S-EPMC9011202 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature