CD8⁺ T-cell exhaustion in the tumor microenvironment of head and neck squamous cell carcinoma determines poor prognosis.

ABSTRACT:

Background

The occurrence of head and neck squamous cell carcinoma (HNSCC) is closely related to the immune system. The integration of traditional treatment methods and immunotherapy will be the future development direction of cancer treatment. But immunotherapy also has its limitations: a lot of basic research is going on, but the translation from basic to clinical is still not enough, and there are still few drugs approved for use.This study aimed to explore the clinical significance of the tumor immune microenvironment in HNSCC.

Methods

Six clinically obtained postoperative cases were analyzed using multiplex immunohistochemistry (mIHC) to observe the tumor immune microenvironment and analyze infiltrating immune cells. Correlations between infiltrating immune cells from T

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9011205 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature