The natural history of breast cancer: a chronological analysis of breast cancer progression using data from the SEER database.

ABSTRACT:

Background

Numerous mathematical models and retrospective analyses have been conducted to explore the natural progression of breast cancer, but there is no precise timeline as to how long it takes breast cancer to progress from stages 0 to IV. Studying the natural history of breast cancer requires the follow-up of a large cohort of patients who received no treatment following diagnosis for a long period, but this has become unpractical in the modern era. In this study, we quantified the natural progression of breast cancer using the Surveillance, Epidemiology, and End Results (SEER) database which was collected the clinical-pathological characteristics and survival data of untreated breast cancer patients.

Methods

We included 12,687 female patients who did not receive surgic

SUBMITTER: Wu J 

PROVIDER: S-EPMC9011255 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature