Quantitative assessment of renal damage in rhesus monkeys with diabetic nephropathy using contrast-enhanced ultrasound.

ABSTRACT:

Background

Diabetic nephropathy (DN) is a common chronic microvascular complication of diabetes. Noninvasive diagnosis of DN is difficult. Contrast-enhanced ultrasound (CEUS), as a functional imaging method, provides noninvasive real-time images and quantitative assessment of renal microvascular perfusion. This study investigated the efficacy of CEUS in discriminating between DN and normal kidneys in rhesus monkeys.

Methods

A total of 12 male rhesus monkeys (DN model group, n=6; normal control group, n=6) were included in this study. The following parameters were evaluated: (I) blood biochemistry; (II) CEUS; and (III) ultrasound-guided renal biopsy.

Results

Pathological and biochemical results showed that all subjects in the lesion group had serious renal damage. Ther

SUBMITTER: Wang H 

PROVIDER: S-EPMC9011263 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature