A new pyroptosis model can predict the immunotherapy response and immune microenvironment characteristics and prognosis of patients with cutaneous melanoma based on TCGA and GEO databases.

ABSTRACT:

Background

Recent studies have shown that pyroptosis is related to cancer development. Our previous study also found that gasdermins (GSDMs) was associated with the tumor immune microenvironment. Therefore, we wanted to observe the relationship between pyroptosis and the immune microenvironment and prognosis of skin cutaneous melanoma (SKCM).

Methods

Pyroptosis-related genes were used for pan-cancer prognostic analysis using the GEPIA2 online analysis website. Prognosis-related genes were clustered using R software and related R packages, and the best clustering results were screened for prognosis analysis. The prognosis-related genes were also used to establish a prognosis-related model. Assess the predictive power of a model by comparing area under the curve (AUC). The

SUBMITTER: Wang YY 

PROVIDER: S-EPMC9011270 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature