A narrative review of the role of the Notch signaling pathway in rheumatoid arthritis.

ABSTRACT:

Background and objective

Rheumatoid arthritis (RA) is a chronic autoimmune disease affected by genetics and the environment factors. Its early diagnosis and treatment are difficult, and the infection risk is serious. The treatment effects for most patients were not significant, which has become a difficult challenge to overcome. Cell signals play an important role in regulating basic cellular activities such as immunity. Notch signaling is a near secretory signal that can affects many processes of cell normal morphogenesis, including the differentiation of pluripotent progenitor cells, apoptosis, cell proliferation and the formation of cell boundary. In addition, the expression and activation of Notch signaling are increased in the synovial cells and vascular endothelial cells of R

SUBMITTER: Zhuang Y 

PROVIDER: S-EPMC9011276 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature