Recent advances in pharmacogenomics research of anti-asthmatic drugs: a narrative review.

ABSTRACT:

Background and objective

Bronchial asthma, a common respiratory disease in children and young adults, is characterized by hyperresponsiveness and reversible narrowing of the airways which manifest clinically as shortness of breath, cough, and/or wheezing. Although its pathogenic mechanism remains unknown, it's known that asthma patients have substantial interindividual variability in drug responsiveness, among which genetic factors play key roles. For improving the understanding of the biological mechanism of asthma and useful recognition of diagnostic and therapeutic targets, and the main purpose of this article is to optimize drug selection by analyzing genes associated with different drug responsiveness in asthmatic patients through the use of genomic techniques.

Methods

SUBMITTER: Li J 

PROVIDER: S-EPMC9011285 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature