Mechanism of Radix Scutellariae in the treatment of influenza A based on network pharmacology and molecular docking.

ABSTRACT:

Background

Radix Scutellariae (RS) has been used to treat influenza for thousands of years in China. However, its mechanisms of action remain unclear. The aim of the present study was to use a network pharmacology and molecular docking-based approach to explore active components and potential molecular mechanisms of RS for influenza A.

Methods

Target genes of RS and influenza A were attained by accessing network databases. We then determined the intersection of both genes through bioinformatics using R and Perl language. The protein-protein interaction (PPI) network was constructed by the STRING website (https://cn.string-db.org). The network analysis was done using Cytoscape software. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were applied

SUBMITTER: Li Q 

PROVIDER: S-EPMC9011286 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature