A pan-cancer analysis of the oncogenic role of secreted phosphoprotein 1 (SPP1) in human cancers.

ABSTRACT:

Background

Emerging evidence suggests that secreted phosphoprotein 1 (SPP1) is involved in tumor cell progression in multiple cancer types. However, the role of SPP1 in different cancers is still not clear.

Methods

We used data from The Cancer Genome Atlas (TCGA) to analyze the multiomic roles of SPP1, including RNA expression, DNA methylation, protein phosphorylation, immune infiltration, and overall survival (OS) in 33 tumor types.

Results

SPP1 is highly expressed in most cancer types, and its methylation variability and mRNA expression level are both correlated with prognosis in multiple cancer types. A higher S234 phosphorylation level was observed in 4 types of tumors, including colon adenocarcinoma (COAD) and lung adenocarcinoma (LUAD). SPP1 expression level was

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9011290 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature