Pectic polysaccharides ameliorate the pathology of ulcerative colitis in mice by reducing pyroptosis.

ABSTRACT:

Background

Ulcerative colitis (UC) is an inflammatory bowel disease which seriously affects the quality of life of patients. There has been an increasing amount of research related to the therapeutic effects and mechanisms of natural plant substances in the treatment of recurrent UC. Rauwolfia verticillata var. Hainanensis is a medicinal plant that is native to Hainan Island, China. Some studies have documented that pectic polysaccharides (PPs) from Rauvolfia inhibited the progression of colon ulcers. However, their mechanisms of action have not been established. Studies have revealed that suppressing pyroptosis can attenuate the damage of experimental colitis. However, it is unclear whether PPs from Rauvolfia verticillata inhibit inflammation through pyroptosis. This study investi

SUBMITTER: Cui LJ 

PROVIDER: S-EPMC9011308 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature