Construction of survival-related co-expression modules and identification of potential prognostic biomarkers of osteosarcoma using WGCNA.

ABSTRACT:

Background

Osteosarcoma (OS) is a primary malignant bone tumor. Patients with different immune characteristics respond differently to chemotherapy and have a lower chance of survival. The potential pathogenesis and therapeutic targets of OS must be investigated further.

Methods

OS expression profile data and clinical information were downloaded from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) and the Gene Expression Omnibus (GEO) databases. The immune-related gene set was obtained from the ImmPort database, and the immune-related gene expression profiles were used for non-negative matrix factorization (NMF) cluster analysis of patients in the 2 databases to find the best clustering number. In the TARGET database, OS patients were classif

SUBMITTER: Bian Y 

PROVIDER: S-EPMC9011312 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature