Lactobacillus plantarum Lp3a improves functional constipation: evidence from a human randomized clinical trial and animal model.

ABSTRACT:

Background

Functional constipation (FC) is a common gastrointestinal (GI) disorder characterized by symptoms of constipation without a clear physiologic or anatomic cause. Gut microbiome dysbiosis has been postulated to be a factor in the development of FC, and treatment with probiotic regimens, including strains of Lactobacillus plantarum (L. plantarum), has demonstrated efficacy in managing symptoms. To further understand the role of L. plantarum in GI health, we conducted an animal study and a randomized, double-blind, placebo-controlled clinical trial to evaluate the effect of a specific sub-strain, Lp3a, on FC.

Methods

For the animal study, male Kunming mice were treated with doses of L. plantarum Lp3a ranging from 0.67 to 2.00 g/kg or an equivalent

SUBMITTER: Zhang C 

PROVIDER: S-EPMC9011319 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature