Directional DBS of the Fornix in Alzheimer's Disease Achieves Long-Term Benefits: A Case Report.

ABSTRACT:

Background

Current treatments for Alzheimer's disease (AD) modulate global neurotransmission but are neither specific nor anatomically directed. Tailored stimulation of target nuclei will increase treatment efficacy while reducing side effects. We report the results of the first directional deep brain stimulation (dDBS) surgery and treatment of a patient with AD in an attempt to slow the progression of the disease in a woman with multi-domain, amnestic cognitive status.

Methods

We aimed to assess the safety of dDBS in patients with AD using the fornix as stimulation target (primary objective) and the clinical impact of the stimulation (secondary objective). In a registered clinical trial, a female patient aged 81 years with a 2-year history of cognitive decline and diagnoses

SUBMITTER: Barcia JA 

PROVIDER: S-EPMC9011335 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature