Ontology highlight
ABSTRACT:
SUBMITTER: Brolin K
PROVIDER: S-EPMC9011339 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Brolin Kajsa K Bandres-Ciga Sara S Leonard Hampton H Makarious Mary B MB Blauwendraat Cornelis C Mata Ignacio F IF Foo Jia Nee JN Pihlstrøm Lasse L Swanberg Maria M Gan-Or Ziv Z Tan Manuela Mx MM
Neurobiology of aging 20210821
Parkinson's disease (PD) is a complex neurodegenerative disorder in which both rare and common genetic variants contribute to disease risk. Multiple genes have been reported to be linked to monogenic PD but these only explain a fraction of the observed familial aggregation. Rare variants in RIC3 have been suggested to be associated with PD in the Indian population. However, replication studies yielded inconsistent results. We further investigate the role of RIC3 variants in PD in European cohort ...[more]