Tannic Acid-Iron Complex-Based Nanoparticles as a Novel Tool against Oxidative Stress.

ABSTRACT: Accumulation of reactive oxygen species in cells leads to oxidative stress, with consequent damage for cellular components and activation of cell-death mechanisms. Oxidative stress is often associated with age-related conditions, as well as with several neurodegenerative diseases. For this reason, antioxidant molecules have attracted a lot of attention, especially those derived from natural sources─like polyphenols and tannins. The main issue related to the use of antioxidants is their inherent tendency to be oxidized, their quick enzymatic degradation in biological fluids, and their poor bioavailability. Nanomedicine, in this sense, has helped in finding new solutions to deliver and protect antioxidants; however, the concentration of the encapsulated molecule in conventional nanosystems c

SUBMITTER: Pucci C 

PROVIDER: S-EPMC9011352 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature