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Characterization of a genetic element carrying the macrolide efflux gene mef(A) in Streptococcus pneumoniae.

ABSTRACT: The mef(A) gene from a clinical isolate of Streptococcus pneumoniae exhibiting the M-type resistance to macrolides was found to be part of the 7,244-bp chromosomal element Tn1207.1, which contained 8 open reading frames. orf2 encodes a resolvase/invertase, and orf5 is a homolog of the macrolide-streptogramin B resistance gene msr(SA).

SUBMITTER: Santagati M 

PROVIDER: S-EPMC90116 | biostudies-literature | 2000 Sep

REPOSITORIES: biostudies-literature

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Characterization of a genetic element carrying the macrolide efflux gene mef(A) in Streptococcus pneumoniae.

Santagati M M   Iannelli F F   Oggioni M R MR   Stefani S S   Pozzi G G  

Antimicrobial agents and chemotherapy 20000901 9

The mef(A) gene from a clinical isolate of Streptococcus pneumoniae exhibiting the M-type resistance to macrolides was found to be part of the 7,244-bp chromosomal element Tn1207.1, which contained 8 open reading frames. orf2 encodes a resolvase/invertase, and orf5 is a homolog of the macrolide-streptogramin B resistance gene msr(SA). ...[more]

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